Deception in Research on the Placebo Effect

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Deception in Research on the Placebo Effect

T he placebo effect is a fascinating yet puzzling phenomenon, which has challenged investigators over the past 50 years. Recently, it has been defi ned as the " positive physiological or psychological changes associated with the use of inert medications, sham procedures, or therapeutic symbols within a healthcare encounter " [1]. Increasing scientifi c inquiry has been aimed at elucidating the ...

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"Run-in" and "washout" periods involving the withholding of medication are widely used in drug research trials in pursuit of both patient safety and scientific reliability. Such no-medication periods can be justified ethically provided that they are apparent to patients, who can thereby properly consent to undergoing them. Less widespread, but still common, is the practice of "single blinding" ...

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ژورنال

عنوان ژورنال: PLoS Medicine

سال: 2005

ISSN: 1549-1676

DOI: 10.1371/journal.pmed.0020262